The PGA Research Group

Giulia De Seriis

I have involed in the project that recently published, Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes in  Journal of the American Chemical Society. In this project we developed the regioselective asymmetric hydrogenation of 1,4-diene which have two different olefins. Under optimized reaction we obtained desired product in moderate to good yields with excellent %ee. The hydrogenated product can be used to prepared useful intermediate.

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Scheme 1. Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes

References:

Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes

Jianguo Liu, Suppachai Krajangsri, Thishana Singh, Giulia De Seriis, Napasawan Chumnanvej, Haibo Wu, and Pher G. Andersson
Journal of the American Chemical Society 2017 139 (41), 14470-14475