The PGA Research Group

Our Research

 

Catalytic asymmetric hydrogenation using hydrogen gas is one of the best methods to induce chirality in prochiral compounds due to high enantioselectivity and atom-economy.(1-3) For the past two decades, the Andersson group has gained experience in the field of iridium-catalyzed asymmetric hydrogenation. During this period, novel N,P-ligands were developed and applied in the hydrogenation of various classes of substrates, including challenging aliphatic- and tetrasubstituted olefins.(4-10) Recent developed protocols include advances in regioselective hydrogenation of dienes, synthesis of chiral fluorine motifs and dynamic kinetic resolution of allylic alcohols.(11-13)

Research fig 1

Current interests lay in:

  • Methodology development using Ir-N,P catalyzed asymmetric hydrogenation, such as;
    • Enantioconvergent hydrogenation where both E- and Z-olefins lead to the same absolute configuration of the product.
    • (Dynamic) kinetic resolution of various classes of functionalized olefins.
    • Synthesis of chiral fluorine scaffolds.
  • Application of developed methodology in total synthesis. (see more info here)

References:

1. X. Cui and K. Burgess, Chem. Rev., 2005, 105, 3272-3296.

2. J. J. Verendel, O. Pàmies, M. Diéguez and P. G. Andersson, Chem. Rev., 2014, 114, 2130-2169.

3. C. Margarita, P. G. Andersson, J. Am. Chem. Soc., 2017, 139, 1346-1356

4. K. Källström, I. Munslow, P. G. Andersson, Chem. Eur. J., 2006, 12, 3194-3200

5. P. Tolstoy, M. Engman, A. Paptchikhine, J. Bergquist, T. L. Church, A. W.-M. Leung, P. G. Andersson, J. Am. Chem. Soc., 2009, 131, 8855-8860

6. J. Mazuela, A. Paptchikhine, O. Pàmies, P. G. Andersson, M. Diéguez, Chem. Eur. J., 2010, 16, 4567-4576

7. J. Mazuela, P. O. Norrby, P. G. Andersson, O. Pàmies, M. Diéguez, J. Am. Chem. Soc., 2011, 133, 13634-13645

8. X. Quan, V. S. Parihar, M. Bera, P. G. Andersson, Eur. J. Org. Chem., 2014, 140–149

9. B.K. Peters, T. Zhou, J. Rujirawanich, A. Cadu, T. Singh, W. Rabten, S. Kerdphon, P. G. Andersson, J. Am. Chem. Soc., 2014, 136, 16557-16562

10. Tetrasubstituted Olefins: S. Kerdphon, S. Ponra, J. Yang, H. Wu, L. Eriksson, P. G. Andersson, ACS Catal., 2019, 9, 6169-6176

11. Regioselective Hydrogenation of Dienes: J. Liu, S. Krajangsri, T. Singh, G. De Seriis, N. Chumnanvej, H. Wu, P. G. Andersson, J. Am. Chem. Soc., 2017, 139, 14470-14475

12. Chiral Fluorine: (a) S. Ponra, W. Rabten, J. Yang, H. Wu, S. Kerdphon, P. G. Andersson, J. Am. Chem. Soc., 2018, 140, 13878-13883; (b) S. Ponra, J. Yang, S. Kerdphon, P. G. Andersson, Angew. Chem. Int. Ed. 2019, 58, 9282–9287

13. DKR of allylic alcohol: J. Liu, S. Krajangsri, J. Yang, J.-Q. Li, P. G. Andersson, Nature Catalysis 2018, 1, 438-443

 

 

You can find more information about the research interests of the group by clicking on the names in the The Group section.

If you are a student insterest in doing Diploma work or Project Work you can Contact Us!