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Introduction

Recent Publications

  • Information for students and staff about the coronavirus

    Stockholm University is monitoring the situation and follows the information and recommendations of the Swedish Public Health Agency and the Ministry of Foreign Affairs regarding this matter.



  • Drop-in vaccination against Covid-19 at Frescati campus

    A vaccination unit will come to the Frescati campus to offer drop-in vaccination against Covid-19 and you can get vaccinated without booking an appointment in advance.



  • World's Top 2% Scientists

    The majority of the PIs at the department are included along with many other eminent fellow scientists in the list of World's Top 2% Scientists! The ranking is based on c-score, a composite indicator for career-long impact. Per Siegbahn, Jan-Erling Bäckvall, Björn Åkermark, Fahmi Himo, Kalman Szabo, Margareta Blomberg, Pher Andersson, Hans Adolfsson, Berit Olofsson and Göran Widmalm are all listed.
    https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000918&fbclid=IwAR25_FFus--1toDVW-cJ_5wRrE9-XT2VCVPU6iWTzmHaCPHNbbJlU8CjvHY

    The list can be downloaded from here:
    https://drive.google.com/file/d/1bUJrvurVVBbxSl9eFZRSHFif7tt30-5U/view?fbclid=IwAR0B6QQzrahBrFJltD6J7-Ln_zn2kuJ-Sz2YQPHn_5KVC3ANNMTlnW_ufus


  • Information regarding teaching autumn 2021



  • The L´réal-Unesco For Women in Science Sweden Prize with support of The Young Academy of Sweden


  • The L´réal-Unesco For Women in Science Sweden Prize with support of The Young Academy of Sweden, aims at highlighting promising women in the early stages of their research career in science and creating role models for future generations. The prize will be awarded next time in 2021. From June 1st until September 27th 2020 the call for application is open If you meet the criteria we look forward to your application.
    Utlysningen är öppen 1 juni - 27 september och du som uppfyller kriterierna är välkommen att ansöka.


  • Prof. Belén Martín-Matute elected in the International Advisory Board of ACS Sustainable Chemistry & Engineering


    • Prof. Belén Martín-Matute

  • Prof. Belén Martín-Matute elected in the International Advisory Board of ACS Sustainable Chemistry & Engineering












  • Professor Berit Olofsson elected in the International Advisory Board of Angewandte


    • Berit Olofsson

  • Berit Olofsson (Stockholm University, Sweden) will join the Angewandte Chemie International Advisory Board in 2020.
    Link







  • Nicklas Selander utsedd till årets lärare på SU 2019


    • Nicklas Selander
  • Nicklas Selander, biträdande lektor vid Institutionen för organisk kemi arbetar kontinuerligt med att utveckla sin undervisning baserat på studenternas återkoppling. Han har på tre år lyckats leda ett utvecklingsarbete av en av de svåraste kurserna vid institutionen där han skapat en tydlig progression med inspelade konceptföreläsningar, filmer om nyckelbegrepp i kursen, som stöd för studenternas förståelseutveckling. Han handleder också assistenter för undervisningen, och fungerar därmed som rollmodell för andra att utvecklas i sitt akademiska lärarskap. Nicklas Selander tar sig an utmaningar, såsom att ha studenter med funktionsnedsättningar i kursgruppen, med professionalitet och systematik – som när han bjöd in till ett möte med studievägledare och berörda studenter för att skapa så goda förutsättningar för lärande som möjligt – för alla studenter. Nicklas Selander uppskattas mycket för sina begripliga och handfasta förklaringar till svåra avsnitt och erbjuder studenterna stöd att förstå det centrala och svåra i en interaktiv miljö.




  • Professor Berit Olofsson mottagare av Lindbomska belöningen


    • Berit Olofsson
  • Lindbomska belöningen 2019, 10 000 kr

    Professor Berit Olofsson,
    Institutionen för organisk kemi,
    Stockholms universitet
    "för hennes forskning rörande utveckling av selektiva organiska reaktioner med användning av hypervalenta jodreagens."




  • The Mendoza group is highlighted in the cover of Angewandte Chemie

  • The recent research by M. Costantini and M. Montesinos in the Mendoza lab in collaboration with AstraZeneca Göteborg has demonstrated a unified approach towards the enantioselective synthesis of carbon stereocenters. Key to this discovery is a new stable and practical reagent that is equivalent to a "chiral C-H unit", which is ubiquitous in organic compounds. Mendoza and his team aim to reduce the gap between custom organic synthesis and conventional construction work, in which a small set of precursors, tools and machinery is routinely used to build distinct objects with different sizes and shapes.This new synthetic concept has been highlighted in the cover of the prestigious journal of the German Chemical Society: Angewandte Chemie.


  • Göran Widmalm får Ulla och Stig Holmquists pris

    Göran Widmalm, professor i organisk kemi vid Stockholms universitet, har utsetts till mottagare av Ulla och Stig Holmquists vetenskapliga pris i organisk kemi 2018.

    Ulla och Stig Holmquists vetenskapliga pris i organisk kemi delas årligen ut till en forskare med huvudsakligen nationell verksamhetsbakgrund inom ämnet organisk kemi och som gjort banbrytande forskningsinsatser inom detta område. Prissumman är cirka två miljoner kronor.

    Motivering:
    Göran Widmalm, professor i organisk kemi, tilldelas priset för sina betydelsefulla insatser inom kolhydratområdet. Han har bedrivit forskning kring NMR-spektroskopisk analys av komplexa kolhydrater och har utvecklat nya syntesmetoder för framställning av oligosackarider och glykokonjugat.

    Priset delas ut vid Uppsala universitets vinterpromotion den 25 januari 2019.

    Läs mer om Ulla och Stig Holmquists vetenskapliga pris i organisk kemi.


  • Kalman Szabo and co-workers have been awarded a KAW grant.



  • Professor Berit Olofsson has been elected as ChemPubSoc Europe Fellow 2016/2017



  • Marcus Reitti is this year's Sigrid Arrhenius fellow

  • The Faculty of Science at Stockholm University has appointed the recipient of the 2018 scholarship from the Sigrid Arrhenius fund. The scholarship rewards an outstanding research project leading to a doctorate. The recipient of the scholarship is awarded SEK 46,000.
  • The winner of this year's scholarship is Marcus Reitti from the Department of Organic Chemistry. Reitti is expected to complete his doctorate by the end of 2018. His research project focuses on development of efficient synthetic methodology under metal-free conditions, and mechanistic studies of reactions with hypervalent iodine reagents.
    • Sigrid Arrhenius fellow

  • Kungligt stipendium till kemist

  • Maxim Galkin, forskare vid Institutionen för organisk kemi i Joseph Samecs forskargrupp, får ett kungligt stipendium på 85 000 kronor för sin forskning kring bomull och plast från rester av svenskt skogsbruk.
  • Stiftelsen Konung Carl XVI Gustafs 50-årsfond för vetenskap, teknik och miljö tillkom i samband med kungens 50-årsdag. Det skedde på initiativ av Kungl. Vetenskaps­akademien, Kungl. Skogs- och Lantbruksakademien, Kungl. Ingenjörs­vetenskaps­akademien och Sveriges Industriförbund (nuv. Svenskt Näringsliv) med ändamål att främja forskning, teknisk utveckling och företagande, som bidrar till uthålligt nyttjande av naturresurserna och bevarande av biologisk mångfald.
  • Stiftelsens styrelse har beslutat dela ut 15 stipendier, varav ett går till Maxim Galkin vid Institutionen för organisk kemi, Stockholms universitet. Kung Carl XVI Gustaf delar ut stipendierna vid en mottagning på Kungliga Slottet den 25 maj.

  • Framtidens förnyelsebara resurser


    • Belén Martín-Matute.
    Foto: Anneli Larsson.
  • Belén Martín-Matute, Institutionen för organkemi, får Göran Gustafssonpriset i kemi 2018 för "utveckling av nya metoder för metallorganisk katalys."
  • Belén Martín-Matute riktar in sig mot utveckling av nya katalytiska processer för att skapa kol-kol och kol-heteroatombindningar. Det handlar bland annat om att omvandla vatten och koldioxid till kemiska produkter utan att behöva hantera farliga mellanled. Heteroatomer, som syre, kväve och halogener (fluor, klor, brom och jod) är vanligt förekommande i läkemedel och jordbrukskemikalier. De bindningarna är därför extra intressanta att skapa.
  • Huvuddelen i Belén Martín-Matutes forskning är att prioritera hållbarhet i metoderna som utvecklas av hennes forskargrupp. Hon använder miljövänliga lösningsmedel och mångsidiga, stabila och strukturellt simpla, men fortfarande effektiva, katalysatorer. Belén Martín-Matutes metoder ger högt utbyte vid milda temperaturer. Hennes forskning fokuserar även på förädling av biomassa och koldioxid för att undvika bildandet av avfall och för att kunna hitta nya förnybara resurser för kemiindustrin.

    • Läs mer om Belén Martín-Matutes forskning: Read more


  • The Japan Research Foundation for Optically Active Compounds
    announces the recipient of

  • The Yamada-Koda Prize 2017
    Jan-E. Bäckvall

  • The Yamada-Koga Prize, consisting of a medal, a plaque, 500,000 Japanese yen and travel expenses to Japan, is awarded every year to a scientist whose research has had a major impact in the fields of the synthesis of optically active compounds. The Prize was founded in 1995 to commemorate the great contributions to the science in this field by the late Professor Shun-ichi Yamada and the late Professor Kenji Koda. The Yamada-Koga Prize will be awarded to Professor Jan-E. Bäckvall on December 15, 2017, at the 27th Symposium on Optically Active Compounds held in Tokyo, Japan.

  • Read more


  • Pris till metallorganisk kemist

  • Uppsala universitet har utsett 2017 års mottagare av Ulla och Stig Holmquists vetenskapliga pris i organisk kemi.

  • Priset går till Kálmán J. Szabó, professor i organisk kemi med inriktning mot metallorganisk kemi vid Stockholms universitet.

    Motiveringen lyder:
    Professor Kálmán J. Szabó får priset för sin skicklighet att syntetisera metallorganiska föreningar vilka till exempel kan innehålla bor eller kisel och som kan användas för framställning av olika typer av bioaktiva föreningar.

    Szabó blandar skickligt användningen av teoretiska metoder och modelleringar som kvantmekanik med experiment för att belysa och förstå kemiska reaktionsförlopp. Detta har lagt grunden till hans utveckling av kemin kring så kallade pincer-komplex för katalys, vilket är vissa typer av metaller som kan binda hårt till organiska molekyler och fungera som katalysatorer.

    Read article (swedish): Kemivärlden Biotech


  • Belén Martín-Matute berättar om vägen till att bli professor

  • Med hjälp av rätt lärare och rätt forskningsstöd vid rätt tidpunkt blev karriärresan verklighet för Belén Martín-Matute, professor inom organisk kemi vid Stockholms universitet.

  • Read article (swedish): Tidningen Innovation



  • More effective and environmentally-friendly methods for chemical synthesis

  • Chemical synthesis of everything from pharmaceuticals to new materials often requires the use of toxic solvents and metals. Wallenberg Academy Fellow Abraham Mendoza will expand the chemists' toolbox with more sustainable methods. Inspired by nature, he uses the energy of light to control and catalyse environmentally friendly chemical reactions.

  • Twentieth century developments in chemical synthesis have been necessary for our modern world; they have been fundamental to the manufacture of effective pharmaceuticals, material for roads and illuminated molecules for mobile displays, to name a few things. The benefits for mankind are reflected in how 58 of 108 Nobel Prizes in Chemistry have been awarded to discoveries related to the development of new synthesis methods.

    However, one problem in chemical synthesis is that reactions are often based upon toxic solvents and expensive metals. Some substances also require synthesis to be carried out in many steps, which increases waste and is expensive. Dr. Abraham Mendoza from Stockholm University is therefore working on the development of more effective and environmentally friendly tools for chemists. Using light energy and cheap elements such as aluminium, lithium and iron, he wakes chemical molecules to life and facilitates chemical reactions. He will also develop chemical catalysts that can enable the re-use of waste from the petrochemical industry.

    - We are developing methods for a faster and more effective manufacture of chemicals using reagents that are already in the labs. But we make them behave differently by using LED-light chains such as the ones you may have at home, Abraham Mendoza says.

    The reactions that Abraham Mendoza is rationalizing are foundational for chemists and may thus contribute to more sustainable chemistry in many different industries.

    - I am very happy for Wallenberg Academy Fellowship giving me and my research group the stability needed to reach such ambitious goal, he says.

    Webpage for Abraham Mendoza


  • Knut och Alice Wallenberg Project Grant for Prof. Belén Martín-Matute

  • Professor Belén Martín-Matute, Department of Organic Chemistry, got 35.785 million kronor for her project "Catalytic Composites for Sustainable Synthesis."

  • The world has an abundance of water and carbon dioxide, but they are too stable to be of interest to industry. However, with one oxygen atom removed, they become hydrogen gas and carbon monoxide respectively. Both of these are extremely useful in plastics, agricultural chemicals and lubricants. The problem is that hydrogen gas is extremely flammable when mixed with air and that carbon monoxide is deadly when breathed. But, if you could use them as soon as they're made you could sidestep that dangerous middle stage.

    ‐ By using a porous composite material, hydrogen gas and carbon monoxide can be used in the next chemical process immediately. So we can use renewable resources without needing complicated experimental setup while also minimising the risk to people who work with the chemicals, says Belén Martín-Matute.

    More information about the project

    Webpage for Belén Martín-Matute



Department of Organic Chemistry


The research activities at the department cover many areas of experimental and theoretical organic chemistry, including selective synthesis, transition metal-catalyzed organic transformations, hypervalent iodine chemistry, green chemistry, PET chemistry and bioorganic chemistry as well as medicinal chemistry at the DDD platform at SciLifeLab.

The education offered at the department includes several courses at the bachelor level, and a master program in organic chemistry. In addition, we offer practical projects in the research front, which regularly attract exchange students to the department. We have a comprehensive research education program, with about 40 PhD students, in organic chemistry.

Recent Publications

Gustav Nestor, Alessandro Ruda, Taigh Anderson, et al. A detailed picture of a protein-carbohydrate hydrogen-bonding network revealed by NMR and MD simulations
Glycobiology		 2021
Per E. M. Siegbahn A quantum chemical approach for the mechanisms of redox-active metalloenzymes
RSC Advances		 2021
Monireh Pourghasemi Lati, Jonas Ståhle, Michael Meyer, et al. A Study of an 8-Aminoquinoline-Directed C(sp2)–H Arylation Reaction on the Route to Chiral Cyclobutane Keto Acids from Myrtenal
Journal of Organic Chemistry		 2021
Man-Bo Li, Jie Yang, Ying Yang, et al. Amino-Supported Palladium Catalyst for Chemo- and Stereoselective Domino Reactions
Angewandte Chemie International Edition		 2021
Rong-Zhen Liao, Jing-Xuan Zhang, Zhenyang Lin, et al. Antiferromagnetically coupled [Fe8S9] cluster catalyzed acetylene reduction in a nitrogenase-like enzyme DCCPCh : Insights from QM/MM calculations
Journal of Catalysis		 2021
Jèssica Margalef, Joseph S. M. Samec Assessing Methodologies to Synthesize α-Sulfenylated Carbonyl Compounds by Green Chemistry Metrics
ChemSusChem		 2021
Denise N. Meyer, Miguel Á. Cortés González, Xingguo Jiang, et al. Base-catalysed F-18-labelling of trifluoromethyl ketones. Application to the synthesis of F-18-labelled neutrophil elastase inhibitors
Chemical Communications		 2021
Davide Di Francesco Catalytic valorization of lignocellulose : Direct and sidestream upgrading approaches 2021
Ya Gao, Jumin Lee, Iain Peter Shand Smith, et al. CHARMM-GUI Supports Hydrogen Mass Repartitioning and Different Protonation States of Phosphates in Lipopolysaccharides
Journal of Chemical Information and Modeling		 2021
T. Makhado, Biswanath Das, R. J. Kriek, et al. Chemical and electrochemical water oxidation mediated by bis(pyrazol-1-ylmethyl)pyridine-ligated Cu(i) complexes
Sustainable Energy & Fuels		 2021
Ferran Planas, Matteo Costantini, Marc Montesinos-Magraner, et al. Combined Experimental and Computational Study of Ruthenium N-Hydroxyphthalimidoyl Carbenes in Alkene Cyclopropanation Reactions
ACS Catalysis		 2021
Ferran Planas, Stephanie V. Kohlhepp, Genping Huang, et al. Computational and Experimental Study of Turbo‐Organomagnesium Amide Reagents : Cubane Aggregates as Reactive Intermediates in Pummerer Coupling
Chemistry - A European Journal		 2021
Haibo Wu Controlling the Reactivity and Selectivity in Iridium- and Rhodium-Catalyzed Asymmetric Hydrogenation 2021
Davide Di Francesco, Christian Dahlstrand, Joakim Löfstedt, et al. Debottlenecking a Pulp Mill by Producing Biofuels from Black Liquor in Three Steps
ChemSusChem		 2021
Jie Liu, Arnar Guđmundsson, Jan-E. Bäckvall Efficient Aerobic Oxidation of Organic Molecules by Multistep Electron Transfer
Angewandte Chemie International Edition		 2021
Man-Bo Li, Jan-E. Bäckvall Efficient Heterogeneous Palladium Catalysts in Oxidative Cascade Reactions
Accounts of Chemical Research		 2021
Mahdi M. Abu-Omar, Katalin Barta, Gregg T. Beckham, et al. Guidelines for performing lignin-first biorefining
Energy & Environmental Science		 2021
Bram B. C. Peters, Jira Jongcharoenkamol, Suppachai Krajangsri, et al. Highly Enantioselective Iridium-Catalyzed Hydrogenation of Conjugated Trisubstituted Enones
Organic Letters		 2021
Emanuel Luna, Seonghoon Kim, Ya Gao, et al. Influences of Vibrio cholerae Lipid A Types on LPS Bilayer Properties
Journal of Physical Chemistry B		 2021
Ning Yuan, Arnar Gudmundsson, Karl P. J. Gustafson, et al. Investigation of the Deactivation and Reactivation Mechanism of a Heterogeneous Palladium(II) Catalyst in the Cycloisomerization of Acetylenic Acids by In Situ XAS
ACS Catalysis		 2021
Erik Weis, Martin A. Hayes, Magnus J. Johansson, et al. Iridium-catalyzed C−H methylation and d3-methylation of benzoic acids with application to late-stage functionalizations
iScience		 2021
Daniels Posevins, Aitor Bermejo-López, Jan-E. Bäckvall Iron-Catalyzed Cross-Coupling of Propargyl Ethers with Grignard Reagents for the Synthesis of Functionalized Allenes and Allenols
Angewandte Chemie International Edition		 2021
Arnar Guđmundsson, Srimanta Manna, Jan-E. Bäckvall Iron(II)-Catalyzed Aerobic Biomimetic Oxidation of Amines using a Hybrid Hydroquinone/Cobalt Catalyst as Electron Transfer Mediator
Angewandte Chemie International Edition		 2021
Srimanta Manna, Wei-Jun Kong, Jan-E. Bäckvall Iron(II)-Catalyzed Aerobic Biomimetic Oxidation of N-Heterocycles
Chemistry - A European Journal		 2021
Haibo Wu, Cristiana Margarita, Jira Jongcharoenkamol, et al. Kinetic resolution of racemic allylic alcohols via iridium-catalyzed asymmetric hydrogenation : scope, synthetic applications and insight into the origin of selectivity
Chemical Science		 2021
Lucas Guillemard, Nikolaos Kaplaneris, Lutz Ackermann, et al. Late-stage C-H functionalization offers new opportunities in drug discovery
Nature Reviews Chemistry		 2021
Stefano Santoro, Fahmi Himo Mechanism of the Kinugasa Reaction Revisited
Journal of Organic Chemistry		 2021
Gerhard Hofer, Xiang Sheng, Simone Braeuer, et al. Metal Ion Promiscuity and Structure of 2,3-Dihydroxybenzoic Acid Decarboxylase of Aspergillus oryzae
ChemBioChem (Print)		 2021
Martin Pauze Multicomponent Catalytic Reactions : Theoretical and Experimental Studies 2021
Kenji Kopf New methods for the synthesis of N-heteroaromatics and imines 2021
Rajdip Chowdhury, Abraham Mendoza N-Hydroxyphthalimidyl diazoacetate (NHPI-DA) : a modular methylene linchpin for the C-H alkylation of indoles dagger
Chemical Communications		 2021
Marta Rachwalak, Joanna Romanowska, Michal Sobkowski, et al. Nucleoside Di- and Triphosphates as a New Generation of Anti-HIV Pronucleotides. Chemical and Biological Aspects
Applied Sciences		 2021
Davide Di Francesco, Kiran Reddy Baddigam, Suthawan Muangmeesri, et al. OrganoSoxhlet : a circular fractionation to produce pulp for textiles 2021
Ferran Planas Quantum Chemical Modelling of Enzymatic and Organometallic Reactions 2021
Oscar Pàmies, Jèssica Margalef, Santiago Cañellas, et al. Recent Advances in Enantioselective Pd-Catalyzed Allylic Substitution : From Design to Applications
Chemical Reviews		 2021
Hua-Wei Guan, Yu-Jie Zhu, Joannes Peters, et al. Recognition of hydrophilic molecules in deep cavitand hosts with water-mediated hydrogen bonds
Chemical Communications		 2021
Jun Sun, Sreenu Jennepalli, Matthew Lee, et al. Removal of per- and polyfluoroalkyl substances (PFAS) from water by ceric(iv) ammonium nitrate
RSC Advances		 2021
Duangkamon Jiraroj, Orhathai Jirarattanapochai, Wipark Anutrasakda, et al. Selective decarboxylation of biobased fatty acids using a Ni-FSM-16 catalyst
Applied Catalysis B: Environmental		 2021
Haibo Wu, Hao Su, Erik J. Schulze, et al. Site- and Enantioselective Iridium-Catalyzed Desymmetric Mono-Hydrogenation of 1,4-Dienes
Angewandte Chemie International Edition		 2021
Chuqiao Dong, Yeol Kyo Choi, Jumin Lee, et al. Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane
Glycobiology		 2021
Benjamin Wiseman, Ram Gopal Nitharwal, Göran Widmalm, et al. Structure of a full-length bacterial polysaccharide co-polymerase
Nature Communications		 2021
Fawad Ahmad, Muneera D. F. Alkahtani, Muhammad Babar Taj, et al. Synthesis of New Naphthyl Aceto Hydrazone-Based Metal Complexes : Micellar Interactions, DNA Binding, Antimicrobial, and Cancer Inhibition Studies
Molecules		 2021
Sybrand Jonker Synthesis of Organoboronic Acids and Applications in Asymmetric Organocatalysis 2021
Denise N. Meyer Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling 2021
Wojciech Plazinski, Mattias U. Roslund, Elin Säwén, et al. Tautomers of N-acetyl-d-allosamine : an NMR and computational chemistry study
Organic and biomolecular chemistry		 2021
Andrew W. Bartling, Michael L. Stone, Rebecca J. Hanes, et al. Techno-economic analysis and life cycle assessment of a biorefinery utilizing reductive catalytic fractionation
Energy & Environmental Science		 2021
Margareta R. A. Blomberg The importance of exact exchange-A methodological investigation of NO reduction in heme-copper oxidases
Journal of Chemical Physics		 2021
Margareta R. A. Blomberg The Redox-Active Tyrosine Is Essential for Proton Pumping in Cytochrome c Oxidase
Frontiers in Chemistry		 2021
Alexander Orebom, Davide Di Francesco, Patrick Shakari, et al. Thermal and Mechanical Properties of Esterified Lignin in Various Polymer Blends
Molecules		 2021
Gabriella Kervefors, Leonard Kersting, Berit Olofsson Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts
Chemistry - A European Journal		 2021
Gabriella Kervefors Transition Metal-Free O-, N- and S-Arylations with Diaryliodonium Salts 2021
Emanuele Azzi, Giovanni Ghigo, Stefano Parisotto, et al. Visible Light Mediated Photocatalytic N‑Radical Cascade Reactivity of γ,δ-Unsaturated N‑Arylsulfonylhydrazones : A General Approach to Structurally Diverse Tetrahydropyridazines
Journal of Organic Chemistry		 2021
Fabiola E. Medina, Mario Prejanò Water Molecules Allow the Intramolecular Activation of the Thiamine Di-Phosphate Cofactor in Human Transketolase : Mechanistic Insights into a Famous Proposal
ACS Catalysis		 2021

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