The PGA Research Group

Jia Zheng

My research is focused on sequential constructions of several chiral centers via Ir-catalyzed asymmetric hydrogenation (Scheme 1). We first attempted the asymmetric hydrogenation of aromatic olefins with our chiral catalyst, affording high enantioselectivity. Subsequently, these products were employed in the Birch reduction, which broke the aromaticity and generated 1,4 dienes/trienes. By the hydrogenations of these 1,4 dienes/trienes, we can create additional chiral centers inside the ring.