The PGA Research Group

Jianguo Liu

I have been involved in the following projects.

1. Asymmetric hydrogenation of allylic alcohols

JG4

This study involved the preparation of a range of allylic alcohols. These allylic alcohols were then hydrogenated, using iridium catalysts that have been previously prepared, to produce chiral alcohols with high yields and excellent enantioselectivity. The selectivity model of the reaction was used to accurately predict the absolute configuration of the hydrogenated products.

2. Application of Asymmetric hydrogenation of allylic alcohols in Synthesis of the key intermediate of Aliskiren

JG5

This study was directed on the application of iridium catalyzed asymmetric hydrogenation of allylic alcohols in the synthesis of a late-stage intermediate of Aliskiren. A total of three synthetic routes were evaluated. The best synthesis relies on asymmetric hydrogenation of an allylic alcohol as a key-step. Full conversion and 94% ee for the allylic alcohol were achieved. The late-stage intermediate of Aliskiren was successfully synthesized in eight steps.

3. Birch Reduction and Asymmetric Hydrogenation

In this project, we want to prepare substrates using birch reduction and do asymmetric hydrogenation using iridium catalysts.

Some substrate group:
JG6
Reference:
1.Peters, B. K.; Liu, J.; Margarita, C.; Andersson, P. G. Chemistry-A European Journal (early view)2015.