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research [2013/12/13 09:12]
gw
research [2016/01/08 13:22] (current)
gw
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The research is focused on understanding structure-dynamics-interaction relationships of carbohydrates in general and glycan-protein interactions in particular. Three different avenues are chosen to this end, viz., (i) organic synthesis; (ii) experimental techniques, especially NMR spectroscopy; and (iii) molecular simulations, in particular molecular dynamics simulations. We carry out investigations on the following subjects: The research is focused on understanding structure-dynamics-interaction relationships of carbohydrates in general and glycan-protein interactions in particular. Three different avenues are chosen to this end, viz., (i) organic synthesis; (ii) experimental techniques, especially NMR spectroscopy; and (iii) molecular simulations, in particular molecular dynamics simulations. We carry out investigations on the following subjects:
  * Development of rapid and robust methodology for the determination of carbohydrate structure, i.e., towards fully automatic structure determination by NMR   * Development of rapid and robust methodology for the determination of carbohydrate structure, i.e., towards fully automatic structure determination by NMR
-  * Chemical and chemo-enzymatic synthesis of oligosaccharides, glycoconjugates, and of protein inhibitors+  * Chemical synthesis of oligosaccharides, glycoconjugates, and of protein inhibitors
  * In depth studies of conformational dynamics of glycoconjugates found in biologically and medically relevant systems   * In depth studies of conformational dynamics of glycoconjugates found in biologically and medically relevant systems
-  * Interaction and docking studies of glycoconjugates and of small organic molecules with proteins in general and enzymes in particular+  * Interaction and docking studies of glycoconjugates and of small organic molecules with proteins in general and enzymes in particular with the aim of improving antibiotic uptake in gram-negative bacteria
The research spans from Glycobiology to Biophysis The research spans from Glycobiology to Biophysis
 
research.txt · Last modified: 2016/01/08 13:22 by gw